Research
During my PhD study,a major theme of my research is about optical coherence tomography, propeling medical diagnostics and forensic methodologies forward. Some projects include:
Multi-scale Multi-speed Optical Coherence Tomography Systems
Robotic-OCT guided inspection and microsurgery of monolithic storage devices
Multi- functional Optical coherence tomography towards intraoperative diagnose of CNS Tumor
High-speed pathology virtual staining technology based on deep learning
Multi-scale Multi-speed Optical Coherence Tomography Systems
- Developed a high-resolution 120kHz 850nm SD-OCT system with 4µm isotropic resolution using self-designed wavenumber linear spectrometer.
- Developed a 200kHz 1310nm SS-OCT system using Axsun laser with high SNR.
- Developed a 10MHz 1310nm SS-OCT system using Pulse-stretched Mode-locked Laser.
- The OCT systems were controlled by a custom-built, multi-threaded graphical user interface software created using the QT platform, written in C++.
Customized Software of OCT systems
Label-free Images acquired using the aboved OCT systems
Robotic arm assisted large area OCT angiography
- Integrated OCT system into a 6-axis robotic arm to enhance its flexibility.
- Proposed a simple method for calibrating OCT and Robotic coordinate.
- Proposed an adaptive multiple-time interval OCTA with a time-efficient scanning protocol.
- High resolution and large field imaging of an irregular sample: micro-vascular image of whole mouse brain.
Vascular imaging of whole superficial brain
Relevent Publications
- B. He et al., “Whole Brain Micro-Vascular Imaging Using Robot Assisted Optical Coherence Tomography Angiography,” in IEEE Journal of Selected Topics in Quantum Electronics, vol. 29, no. 4: Biophotonics, pp. 1-9, July-Aug. 2023 (feature article in OCT news)
- B. He et al. “Optical coherence tomography angiography with adaptive multi‐time interval“[J]. Journal of Biophotonics, 2023, 16(5): e202200340. (cover paper)
Robotic-OCT guided inspection and microsurgery of monolithic storage devices
- Non-destructive detection of the underlying PCB traces of the MSD cards.
- With proposed continuous scanning strategy, the robotic-OCT provides automatic, precise, flexible, and repeatable imaging with an adjustable field-of-view (FOV).
- Combined with a laser ablation system, the robotic-OCT can serve as a microsurgical tool to selectively remove targeted areas of the insulating layer while only exposing relevant pins to enhance data recovery efficiency.
OCT reveals the hidden layout of MSDs
OCT and laser ablation system are integrated
Relevent Publications
- B. He. et al. (2023). “Robotic-OCT guided inspection and microsurgery of monolithic storage devices”. Nature Communications, 14(1), 5701.
- Reported by Tsinghua news website.
Multi-functional Optical coherence tomography towards intraoperative diagnose of CNS Tumor
- Collaborating with the neurosurgery department of Tsinghua Chang Gung Hospital
- Tumor detection and segmentation with deep learning: Unet-3D
- Evaluation of tumor growth in mice using structural and 3D-vascular information.
- Assessment of drug metabolism response in tumor vasculature.
- Intraoperative OCT imaging of human being.
Brain Tumor imaging of Animals
Tumor imaging of Human
Relevent Publications
Will coming soon
High-speed pathology virtual staining technology based on deep learning
Virtual staining of OCT based on deep learning
